AFP is a glycoprotein homologous albumin, synthesized during fetal gastrointestinal tract, liver and yolk sac.
In adults – increased, transient or persistent levels of AFP – in benign liver disease and liver regeneration processes; very high levels are associated with primitive hepatic carcinoma tumors and testicular germ origin, ovarian or extra-gonadal.
Directions to determine AFP:
As a tumor marker for:
• suspected hepatocellular carcinoma;
• non-seminoma germ tumors of testicular origin, ovarian or extra-gonadal;
• monitoring the treatment of patients with germ tumors or carcinoma hepatocelular2.
In patients with germ tumors AFP can be determined with total HCG. These markers in testicular cancer should be assessed before orchiectomy and then serially measured after surgery.
• monitoring patients with cirrhosis of liver cancer early detection;
• monitoring patients at high risk of germ tumors (cryptorchidism, monozygotic twins, one of them having testicular cancer).
Method – ELISA.
Normal values: 0-10 ng / mL
Increases in AFP may be registered in other tumors: gastrointestinal, pancreatic, lung.
Among benign diseases in which increased levels of AFP may occur include: hepatitis, cirrhosis, biliary obstruction.