TS is a test for the investigation of primary hemostasis and is thus an indicator of vascular and platelet phases efficiency. TS depends on the function and platelet counts, the presence of plasmatic adhesion proteins, vascular wall matrix integrity.
The patient will not take drugs that contain aspirin for 7 days before the test and shall refrain from drinking alcoholic beverages.
Reference values - 1-4 minutes (Duke method).
1. thrombocytopenia: – to 80000 / ¶l, TS will be ~ 10 minutes to 40000 / TS ¶l will be ~ 20 minutes to less than 10,000 / ¶l, TS will be> 30 minutes if platelet function is normal.
2 .. impaired platelet function
– Hereditary von Willebrand disease, Glanzmann’s thrombasthenia, Bernard-Soulier syndrome, Wiskott-Aldrich syndrome, Chediak-Higashi syndrome;
– Acquired: uremia, paraproteinemias (multiple myeloma, Waldenstrom’s macroglobulinemia), myeloproliferative syndromes, acute and chronic viral infections, severe liver failure, drugs.
3. Secondary hemostasis disorders: 20% of patients with hemophilia, 30% of patients with factor V deficiency, in some cases afibrinogenemia.
4. Some diseases of connective tissue: Ehlers-Danlos syndrome. Increased TS in the presence of a normal platelet count indicates the presence of von Willebrand disease or platelet dysfunction.
Increases: aspirin, NSAIDs, antibiotics (penicillins, cephalosporins, nitrofurantoin), tricyclic antidepressants (imipramine, amitriptyline), phenothiazines (chlorpromazine, promethazine), anesthetics (halotanl), methylxanthines (caffeine, theophylline, aminophylline), other (dextrans, calcium channel blockers, beta-blockers, nitrates, oral anticoagulants, heparin and contrast agents).